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acid blob [1 record]

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Record 1 1989-06-16

English

Subject field(s)
  • Translation (General)
  • Biochemistry
CONT

The DNA-binding domains appear to have well-defined structural motifs: by contrast, mutational studies of the activator domains suggest a disquieting picture of a conformationally ill-defined polypeptide that can function almost irrespective of sequence, provided only that there is a sufficient excess of acidic residues clustered or peppered about. Thus, the elegant molecular machinery that so reliably controls expression of eukaryotic polymerase II-transcribed genes relies on nearly shapeless molecular components dubbed "acid blobs" or perhaps more aptly "negative noodles".

French

Domaine(s)
  • Traduction (Généralités)
  • Biochimie

Spanish

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